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Infection and Immunity, May 2002, p. 2676-2680, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2676-2680.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Induction of Protective Immunity to Listeria monocytogenes by Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain

Toshi Nagata,* Taiki Aoshi, Mina Suzuki, Masato Uchijima, Yeung-Hyen Kim, Zhibo Yang, and Yukio Koide

Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192, Japan

Received 23 July 2001/ Returned for modification 28 September 2001/ Accepted 24 January 2002

Listeria epitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated invariant chain peptide (CLIP) region was replaced by a Listeria Th epitope. Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-{gamma}- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192, Japan. Phone and fax: 81-53-435-2335. E-mail: tnagata{at}hama-med.ac.jp.

Editor: S. H. E. Kaufmann

Infection and Immunity, May 2002, p. 2676-2680, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2676-2680.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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