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Infection and Immunity, May 2002, p. 2708-2714, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2708-2714.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Yersinia pseudotuberculosis Produces a Cytotoxic Necrotizing Factor

Hank A. Lockman,1,2* Rebecca A. Gillespie,1 Beth D. Baker,1 and Elizabeth Shakhnovich1

Children's Research Institute, Children's Hospital,1 Division of Molecular Medicine, Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio2

Received 30 November 2001/ Returned for modification 16 January 2002/ Accepted 1 February 2002

Cell extracts from Yersinia pseudotuberculosis induced multinucleation in HEp-2 cells in a manner similar to the effect caused by Escherichia coli cytotoxic necrotizing factor (CNF). The activity was not dependent on the Yersinia 70-kb virulence plasmid, and the activity was not inhibited by antibodies capable of neutralizing E. coli CNF type 1. The nucleotide sequence of the Yersinia cnf gene was 65.1% identical to the E. coli cnf gene.

* Corresponding author. Mailing address: Children's Research Institute, Children's Hospital, 700 Children's Dr., Columbus, OH 43205-2696. Phone: (614) 722-2680. Fax: (614) 722-3273. E-mail: lockmanh{at}pediatrics.ohio-state.edu.

Editor: J. T. Barbieri

Infection and Immunity, May 2002, p. 2708-2714, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2708-2714.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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