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Infection and Immunity, May 2002, p. 2721-2724, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2721-2724.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Passive Immunization with Bovine Milk Containing Antibodies to a Cell Surface Protein Antigen-Glucosyltransferase Fusion Protein Protects Rats against Dental Caries{dagger}

Morihide Mitoma,1 Takahiko Oho,1* Naoko Michibata,2 Kaoru Okano,2 Yutaka Nakano,2 Masataka Fukuyama,2 and Toshihiko Koga1,{ddagger}

Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582,1 University Farm, Kyushu University Faculty of Agriculture, Fukuoka 811-2307, Japan2

Received 3 December 2001/ Returned for modification 11 January 2002/ Accepted 14 February 2002

Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.

* Corresponding author. Mailing address: Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Phone: 81-92-642-6353. Fax: 81-92-642-6354. E-mail: oho{at}dent.kyushu-u.ac.jp.

{dagger} This paper is dedicated to the memory of Toshihiko Koga.

Editor: J. D. Clements

{ddagger} Deceased.

Infection and Immunity, May 2002, p. 2721-2724, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2721-2724.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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