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Infection and Immunity, May 2002, p. 2725-2729, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2725-2729.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis

Flavia De Bernardis, Maria Boccanera, Daniela Adriani, Antonietta Girolamo, and Antonio Cassone*

Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, 00161 Rome, Italy

Received 30 July 2001/ Returned for modification 1 November 2001/ Accepted 28 January 2002

Oophorectomized, estrogen-treated rats were immunized by the intravaginal or intranasal route with a mannoprotein extract (MP) or secreted aspartyl proteinases (Sap) of Candida albicans, with or without cholera toxin as a mucosal adjuvant. Both routes of immunization were equally effective in (i) inducing anti-MP and anti-Sap vaginal antibodies and (ii) conferring a high degree of protection against the vaginal infection by the fungus. These data suggest that appropriate fungal antigens and adjuvant can be used to protect against candidal vaginitis, by either route.

* Corresponding author. Mailing address: Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 390649387113. Fax: 390649387112. E-mail: cassone{at}iss.it.

Editor: R. N. Moore

Infection and Immunity, May 2002, p. 2725-2729, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2725-2729.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cassone, A., De Bernardis, F., Santoni, G. (2007). Anticandidal Immunity and Vaginitis: Novel Opportunities for Immune Intervention. Infect. Immun. 75: 4675-4686 [Full Text]  
  • De Bernardis, F., Lucciarini, R., Boccanera, M., Amantini, C., Arancia, S., Morrone, S., Mosca, M., Cassone, A., Santoni, G. (2006). Phenotypic and Functional Characterization of Vaginal Dendritic Cells in a Rat Model of Candida albicans Vaginitis. Infect. Immun. 74: 4282-4294 [Abstract] [Full Text]  
  • Torosantucci, A., Bromuro, C., Chiani, P., De Bernardis, F., Berti, F., Galli, C., Norelli, F., Bellucci, C., Polonelli, L., Costantino, P., Rappuoli, R., Cassone, A. (2005). A novel glyco-conjugate vaccine against fungal pathogens. JEM 202: 597-606 [Abstract] [Full Text]  
  • Santoni, G., Boccanera, M., Adriani, D., Lucciarini, R., Amantini, C., Morrone, S., Cassone, A., De Bernardis, F. (2002). Immune Cell-Mediated Protection against Vaginal Candidiasis: Evidence for a Major Role of Vaginal CD4+ T Cells and Possible Participation of Other Local Lymphocyte Effectors. Infect. Immun. 70: 4791-4797 [Abstract] [Full Text]  


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