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Infection and Immunity, June 2002, p. 2982-2988, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.2982-2988.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Malaria-Induced Acquisition of Antibodies to Plasmodium falciparum Variant Surface Antigens

Michael F. Ofori,1 Daniel Dodoo,1 Trine Staalsoe,2 Jørgen A. L. Kurtzhals,1,2,{dagger} Kwadwo Koram,1 Thor G. Theander,2 Bartholomew D. Akanmori,1 and Lars Hviid2*

Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana,1 Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark2

Received 4 October 2001/ Returned for modification 12 December 2001/ Accepted 26 February 2002

In areas of intense Plasmodium falciparum transmission, protective immunity is acquired during childhood in parallel with acquisition of agglutinating antibodies to parasite-encoded variant surface antigens (VSA) expressed on parasitized red blood cells. In a semi-immune child in such an area, clinical disease is caused mainly by parasites expressing VSA not recognized by preexisting VSA-specific antibodies in that child. Such malaria episodes are known to cause an increase in agglutinating antibodies specifically recognizing VSA expressed by the parasite isolate causing the illness, whereas antibody responses to other parasite isolates are relatively unaffected. However, the detailed kinetics of this VSA antibody acquisition are unknown and hence were the aim of this study. We show that P. falciparum malaria in Ghanaian children generally caused a rapid and sustained increase in variant-specific VSA antibody levels, while more transient and limited increases in levels of antibodies to VSA expressed by other parasite isolates were also seen. Plasma VSA antibody levels were positively correlated with the age of the healthy plasma donors but negatively correlated with the age of the parasite donors (the malaria patient). The data from this first detailed longitudinal study of acquisition of VSA antibodies support the hypothesis that naturally acquired protective immunity to P. falciparum malaria is mediated, at least in part, by VSA-specific antibodies.

* Corresponding author. Mailing address: Department of Infectious Diseases M7641, Rigshospitalet, Tagensvej 20, 2200 Copenhagen N, Denmark. Phone: 45 35 45 79 57. Fax: 45 35 45 76 44. E-mail: lhcmp{at}rh.dk.

Editor: S. H. E. Kaufmann

{dagger} Present address: Statens Seruminstitut, 2300 Copenhagen, Denmark.

Infection and Immunity, June 2002, p. 2982-2988, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.2982-2988.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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