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Infection and Immunity, June 2002, p. 3281-3283, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3281-3283.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Reevaluation of the Role of HWP1 in Systemic Candidiasis by Use of Candida albicans Strains with Selectable Marker URA3 Targeted to the ENO1 Locus

Paula Sundstrom,1,2* Jim E. Cutler,3,{dagger} and Janet F. Staab1

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine and Public Health,1 Department of Microbiology, The Ohio State University, Columbus, Ohio 43210,2 Department of Microbiology, Montana State University, Bozeman, Montana 597173

Received 14 December 2001/ Returned for modification 1 February 2002/ Accepted 20 March 2002

Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of URA3 contributed to the severity of murine systemic candidiasis in BALB/c mice.

* Corresponding author. Mailing address: Department of Molecular Virology, Immunology, and Medical Genetics, 333 W. 10th Ave., The Ohio State University College of Medicine and Public Health, Columbus, OH 43210-1239. Phone: (614) 292-5525. Fax: (614) 292-9805. E-mail: sundstrom.1{at}osu.edu.

Editor: T. R. Kozel

{dagger} Present address: Research Institute for Children, Children's Hospital, New Orleans, LA 70118.

Infection and Immunity, June 2002, p. 3281-3283, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3281-3283.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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