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Infection and Immunity, June 2002, p. 3284-3286, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3284-3286.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection

Rogier J. L. Stuyt,1 Mihai G. Netea,1 Ineke Verschueren,1 Giamila Fantuzzi,2 Charles A. Dinarello,2 Jos W. M. Van der Meer,1 and Bart Jan Kullberg1*

Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands,1 Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado2

Received 27 August 2001/ Returned for modification 9 October 2001/ Accepted 20 March 2002

In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-{gamma})-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-{gamma}.

* Corresponding author. Mailing address: Department of Medicine (541), Nijmegen University Medical Center St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3618819. Fax: 31-24-3541734. E-mail: B.Kullberg{at}AIG.AZN.NL.

Editor: T. R. Kozel

Infection and Immunity, June 2002, p. 3284-3286, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3284-3286.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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