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Infection and Immunity, June 2002, p. 3287-3289, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3287-3289.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Protection of Mice against Coccidioides immitis Intranasal Infection by Vaccination with Recombinant Antigen 2/PRA

Lisa Shubitz,1,2 Tao Peng,1,2,3 Robert Perrill,1,2 Julie Simons,1,2 Kris Orsborn,1,2,3 and John N Galgiani1,2,3,4*

Valley Fever Center for Excellence,1 Medicine and Subspecialties Program,4 Research Program, Southern Arizona Veterans Affairs Health Care System,2 Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona 857233

Received 2 October 2001/ Returned for modification 26 December 2001/ Accepted 21 March 2002

Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.

* Corresponding author. Mailing address: Valley Fever Center for Excellence 3601 South Sixth Ave., Tucson, AZ 85723. Phone: (520) 629-4777. Fax: (520) 629-4738. E-mail: spherule{at}u.arizona.edu.

Editor: T. R. Kozel

Infection and Immunity, June 2002, p. 3287-3289, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3287-3289.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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