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Infection and Immunity, June 2002, p. 3290-3294, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3290-3294.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Characterization of the spv Locus in Salmonella enterica Serovar Arizona

Stephen J. Libby,1 Marc Lesnick,2 Patricia Hasegawa,2 Michael Kurth,2,{dagger} Christopher Belcher,2,{ddagger} Joshua Fierer,2,3,4 and Donald G. Guiney2*

Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695-7615the,1 Departments of Medicine,2 Pathology, School of Medicine, University of California at San Diego, La Jolla, California 92093,3 Veterans Affairs Healthcare System, San Diego, California 921614

Received 31 October 2001/ Returned for modification 16 January 2002/ Accepted 28 February 2002

Salmonella enterica serovar Arizona (S. enterica subspecies IIIa) is a common Salmonella isolate from reptiles and can cause serious systemic disease in humans. The spv virulence locus, found on large plasmids in Salmonella subspecies I serovars associated with severe infections, was confirmed to be located on the chromosome of serovar Arizona. Sequence analysis revealed that the serovar Arizona spv locus contains homologues of spvRABC but lacks the spvD gene and contains a frameshift in spvA, resulting in a different C terminus. The SpvR protein functions as a transcriptional activator for the spvA promoter, and SpvB and SpvC are highly conserved. The analysis supports the proposal that the chromosomal spv sequence more closely corresponds to the ancestral locus acquired during evolution of S. enterica, with plasmid acquisition of spv genes in the subspecies I strains involving addition of spvD and polymorphisms in spvA.

* Corresponding author. Mailing address: University of California, 9500 Gilman Dr., La Jolla, CA 92093-0640. Phone: (858) 534-6030. Fax: (858) 534-6020. E-mail: dguiney{at}ucsd.edu.

Editor: J. T. Barbieri

{dagger} Present address: Department of Biology, Poway High School, Poway, CA 92064.

{ddagger} Present address: Department of Pediatrics, Stanford University, Stanford, CA 94305.

Infection and Immunity, June 2002, p. 3290-3294, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3290-3294.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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