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Infection and Immunity, July 2002, p. 3621-3626, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3621-3626.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Neisseria lactamica Protects against Experimental Meningococcal Infection

Kerry J. Oliver,1 Karen M. Reddin,1 Philippa Bracegirdle,1 Michael J. Hudson,1 Ray Borrow,2 Ian M. Feavers,3 Andrew Robinson,1 Keith Cartwright,4 and Andrew R. Gorringe1*

Centre for Applied Microbiology and Research, Salisbury SP4 0JG,1 Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR,2 National Institute for Biological Standards and Control, South Mimms, Potters Bar EN6 3QG,3 Public Health Laboratory, Gloucestershire Royal Hospital, Gloucester GL1 3NN, United Kingdom4

Received 29 November 2001/ Returned for modification 11 March 2002/ Accepted 10 April 2002

Immunological and epidemiological evidence suggests that the development of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica. We report here that immunization with N. lactamica killed whole cells, outer membrane vesicles, or outer membrane protein (OMP) pools and protected mice against lethal challenge by a number of diverse serogroup B and C meningococcal isolates in a model of bacteremic infection. Sera raised to N. lactamica killed whole cells, OMPs, or protein pools were found to cross-react with meningococcal isolates of a diverse range of genotypes and phenotypes. The results confirm the potential of N. lactamica to form the basis of a vaccine against meningococcal disease.

* Corresponding author. Mailing address: Centre for Applied Microbiology and Research, Salisbury SP4 0JG, United Kingdom. Phone: 01980 612267. Fax: 01980 611096. E-mail: andrew.gorringe{at}camr.org.uk.

Editor: E. I. Tuomanen

Infection and Immunity, July 2002, p. 3621-3626, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3621-3626.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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