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Infection and Immunity, July 2002, p. 3935-3938, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3935-3938.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Recruitment of Mammalian Cell Fibronectin to the Surface of Chlamydia trachomatis

Betsy J. Kleba,1 Erin Banta,1 Erika A. Lindquist,1 and Richard S. Stephens1,2*

Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720,1 the Francis I. Proctor Foundation, University of California, San Francisco, California 941432

Received 22 January 2002/ Returned for modification 21 February 2002/ Accepted 2 April 2002

Pathogenic bacteria exploit the presence of various host cell molecules in order to colonize new tissues. Fibronectin is involved in a wide range of cell functions in vivo, and staphylococci, streptococci, and gonococci have evolved mechanisms to utilize this glycoprotein to mediate host cell binding. We show that elementary bodies (EB) from two biovars of Chlamydia trachomatis recruit fibronectin to their surfaces upon lysis of the host cell. We also demonstrate that a heparan sulfate lyase-sensitive molecule on chlamydial EB is responsible for binding at least a portion of this fibronectin.

* Corresponding author. Mailing address: Division of Infectious Diseases, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720. Phone: (510) 643-9900. Fax: (510) 643-1537. E-mail: rss{at}uclink4.berkeley.edu.

Editor: D. L. Burns

Infection and Immunity, July 2002, p. 3935-3938, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3935-3938.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stephens, R. S., Poteralski, J. M., Olinger, L. (2006). Interaction of Chlamydia trachomatis with Mammalian Cells Is Independent of Host Cell Surface Heparan Sulfate Glycosaminoglycans. Infect. Immun. 74: 1795-1799 [Abstract] [Full Text]  


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