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Infection and Immunity, July 2002, p. 3939-3943, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3939-3943.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Purified Malaria Pigment (Hemozoin) Enhances Dendritic Cell Maturation and Modulates the Isotype of Antibodies Induced by a DNA Vaccine

Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore,¹ Division of Viral Products, Center for Biological Evaluation and Research/Food and Drug Administration, Bethesda, Maryland²

Received 28 January 2002/ Returned for modification 11 March 2002/ Accepted 24 March 2002

Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when coadministered with a DNA vaccine plasmid encoding Pfs25, a Plasmodium falciparum transmission-blocking antigen.

Editor: W. A. Petri, Jr.

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