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Infection and Immunity, July 2002, p. 3953-3958, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3953-3958.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Analogous Cytokine Responses to Burkholderia pseudomallei Strains Contrasting in Virulence Correlate with Partial Cross-Protection in Immunized Mice

Glen C. Ulett,1,2* Natkunam Ketheesan,1,2 Timothy W. Clair,1 Catriona L. McElnea,1 Jodie L. Barnes,1 and Robert G. Hirst1

Department of Microbiology and Immunology,1 School of Medicine, James Cook University, Townsville, Queensland, Australia 48112

Received 17 December 2001/ Returned for modification 27 March 2002/ Accepted 10 April 2002

Cytokine mRNA levels were assessed in Burkholderia pseudomallei-susceptible BALB/c mice and B. pseudomallei-resistant C57BL/6 mice following administration of a sublethal dose of less virulent (LV) B. pseudomallei, a candidate immunogen tested for protection against a highly virulent (HV) challenge. Compared on the basis of the bacterial loads, the cytokine patterns induced by HV and LV B. pseudomallei were similar, involving gamma interferon, interleukin-10, and other cytokines. Partial cross-protection between B. pseudomallei strains is shown to be associated with cytokine profiles involving both type 1 and type 2 cytokines.

* Corresponding author. Mailing address: Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105-2794. Phone: (901) 495-3486. Fax: (901) 495-3099. E-mail: Glen.Ulett{at}stjude.org.

Editor: J. D. Clements

Infection and Immunity, July 2002, p. 3953-3958, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3953-3958.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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