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Infection and Immunity, July 2002, p. 3962-3964, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3962-3964.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Fibrinogen Binding to Intercellular Adhesion Molecule 1: Implications for Plasmodium falciparum Adhesion

Carolyn Gray and Alister Craig*

Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom

Received 22 January 2002/ Returned for modification 28 February 2002/ Accepted 10 April 2002

Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

* Corresponding author. Mailing address: Liverpool School of Tropical Medicine, Pembroke Pl., Liverpool L3 5QA, United Kingdom. Phone: 44 (0)151 705 3161. Fax: 44 (0)151 708 9007. E-mail: agcraig{at}liverpool.ac.uk.

Editor: B. B. Finlay

Infection and Immunity, July 2002, p. 3962-3964, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3962-3964.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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