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 Previous Article

Infection and Immunity, July 2002, p. 3982-3984, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3982-3984.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Treponema denticola Is Resistant to Human ß-Defensins

Catherine A. Brissette1 and Sheila A. Lukehart1,2*

Departments of Pathobiology,1 Medicine, University of Washington, Seattle, Washington 981952

Received 8 November 2001/ Returned for modification 17 January 2002/ Accepted 25 March 2002

Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodontal disease. Because T. denticola lacks lipopolysaccharides that serve as targets for human ß-defensin (hßD) binding, we postulated that T. denticola would resist killing by hßD. We showed that T. denticola is resistant to hßD-1 and -2. Protease inhibitors did not enhance killing of T. denticola by hßD-2, suggesting that degradation of hßD-2 by treponemal proteases is not a major factor in T. denticola resistance.

* Corresponding author. Mailing address: Department of Medicine, Box 359779, Harborview Medical Center. 325 Ninth Ave., Seattle, WA 98104. Phone: (206) 341-5362. Fax: (206) 341-5363. E-mail: lukehart{at}u.washington.edu.

Editor: V. J. DiRita

Infection and Immunity, July 2002, p. 3982-3984, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3982-3984.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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