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Infection and Immunity, August 2002, p. 4682-4686, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4682-4686.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Colony-Stimulating Factor 1-Dependent Cells Protect against Systemic Infection with Listeria monocytogenes but Facilitate Neuroinvasion

Department of Neuroscience,¹ Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden,³ Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark²

Received 28 February 2002/ Returned for modification 17 April 2002/ Accepted 2 May 2002

By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor 1 and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes.

Editor: J. D. Clements

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