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Infection and Immunity, August 2002, p. 4682-4686, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4682-4686.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Colony-Stimulating Factor 1-Dependent Cells Protect against Systemic Infection with Listeria monocytogenes but Facilitate Neuroinvasion

Yuxuan Jin,1 Lone Dons,2 Krister Kristensson,1 and Martin E. Rottenberg3*

Department of Neuroscience,1 Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden,3 Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark2

Received 28 February 2002/ Returned for modification 17 April 2002/ Accepted 2 May 2002

By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor 1 and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes.

* Corresponding author. Mailing address: Microbiology and Tumorbiology Center, Karolinska Institutet, Nobels väg 16, 171 77 Stockholm, Sweden. Phone: 46-8-728 6696. Fax: 46-8-32 8878. E-mail: Martin.Rottenberg{at}mtc.ki.se.

Editor: J. D. Clements

Infection and Immunity, August 2002, p. 4682-4686, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4682-4686.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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