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Infection and Immunity, August 2002, p. 4687-4691, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4687-4691.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

cag+ Helicobacter pylori Induces Homotypic Aggregation of Macrophage-Like Cells by Up-Regulation and Recruitment of Intracellular Adhesion Molecule 1 to the Cell Surface

Stefan Moese, Matthias Selbach, Thomas F. Meyer,* and Steffen Backert

Abteilung Molekulare Biologie, Max-Planck-Institut für Infektionsbiologie, D-10117 Berlin, Germany

Received 6 March 2002/ Returned for modification 16 April 2002/ Accepted 22 May 2002

Infection with cag+ but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule 1 is up-regulated and recruited to the cell surface of infected cells and mediates the aggregation via lymphocyte function-associated molecule 1. This signaling may regulate cell-cell interactions and inflammatory responses.

* Corresponding author. Mailing address: Max-Planck-Institut für Infektionsbiologie, Abt. Molekulare Biologie, Schumannstr. 21/22, D-10117 Berlin, Germany. Phone: 49 30 28 46 04 02. Fax: 49 30 28 46 04 01. E-mail: meyer{at}mpiib-berlin.mpg.de.

Editor: E. I. Tuomanen

Infection and Immunity, August 2002, p. 4687-4691, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4687-4691.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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