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Infection and Immunity, August 2002, p. 4692-4696, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4692-4696.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Orientia tsutsugamushi Inhibits Apoptosis of Macrophages by Retarding Intracellular Calcium Release

Mee-Kyung Kim,1 Seung-Yong Seong,2,3 Ju-Young Seoh,4 Tae-Hee Han,5 Hyeon-Je Song,6 Ji-Eun Lee,7 Jung-Hoon Shin,7 Byung-Uk Lim,1 and Jae-Seung Kang1*

Departments of Microbiology,1 Physiology, Inha University College of Medicine, Inchon 400-103,7 Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 110-799,2 Department of Microbiology, Ehwa Womans University College of Medicine, Seoul 158-710,4 Department of Microbiology and Immunology, Sungkyunkwan University School of Medicine, Suwon 440-746,5 Microbiology Division, Jeollanam-do Institute of Health and Environment, Kwangju 502-810, Republic of Korea,6 Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208943

Received 7 December 2001/ Returned for modification 2 April 2002/ Accepted 6 May 2002

Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection. Beauvericin-induced calcium redistribution was significantly reduced and retarded in cells infected with O. tsutsugamushi. Antiapoptotic activities of O. tsutsugamushi in infected cells are most probably due to inhibition of the increase in the cytosolic calcium concentration.

* Corresponding author. Mailing address: Department of Microbiology, Inha University College of Medicine, Jungsuk B/D, 3rd St., Shinheung-Dong, Choong-Gu, Inchon 400-103, Republic of Korea. Phone: 82-32-890-0952. Fax: 82-32-881-8559. E-mail: jaeskang{at}inha.ac.kr.

Editor: A. D. O'Brien

Infection and Immunity, August 2002, p. 4692-4696, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4692-4696.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chu, H., Lee, J.-H., Han, S.-H., Kim, S.-Y., Cho, N.-H., Kim, I.-S., Choi, M.-S. (2006). Exploitation of the Endocytic Pathway by Orientia tsutsugamushi in Nonprofessional Phagocytes. Infect. Immun. 74: 4246-4253 [Abstract] [Full Text]  
  • Sukumaran, S. K., Selvaraj, S. K., Prasadarao, N. V. (2004). Inhibition of Apoptosis by Escherichia coli K1 Is Accompanied by Increased Expression of BclXL and Blockade of Mitochondrial Cytochrome c Release in Macrophages. Infect. Immun. 72: 6012-6022 [Abstract] [Full Text]  


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