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Infection and Immunity, August 2002, p. 4716-4720, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4716-4720.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

CD40 Ligand (CD154) Does Not Contribute to Lymphocyte-Mediated Inhibition of Virulent Mycobacterium tuberculosis within Human Monocytes

Rhonda Larkin,1 Christopher D. Benjamin,2 Yen-Ming Hsu,2 Qing Li,1 Lynn Zukowski,1 and Richard F. Silver1,3,4*

Divisions of Pulmonary and Critical Care Medicine,1 Infectious Diseases, Case Western Reserve University School of Medicine,3 University Hospitals of Cleveland, Cleveland, Ohio,4 Biogen, Inc., Cambridge, Massachusetts2

Received 16 May 2001/ Returned for modification 26 June 2001/ Accepted 15 April 2002

Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood lymphocytes and antigen-specific CD4+ T-cell lines likewise was not reduced by blocking anti-CD40L monoclonal antibody 5c8.

* Corresponding author. Mailing address: Division of Pulmonary and Critical Care Medicine, Biomedical Research Building, Room 1030, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106-4984. Phone: (216) 368-1151. Fax: (216) 368-2034. E-mail: rfs4{at}po.cwru.edu.

Editor: S. H. E. Kaufmann

Infection and Immunity, August 2002, p. 4716-4720, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4716-4720.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Andrade, R. M., Wessendarp, M., Subauste, C. S. (2003). CD154 Activates Macrophage Antimicrobial Activity in the Absence of IFN-{gamma} through a TNF-{alpha}-Dependent Mechanism. J. Immunol. 171: 6750-6756 [Abstract] [Full Text]  


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