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Infection and Immunity, August 2002, p. 4721-4725, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4721-4725.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of the High-Affinity Zinc Uptake znuABC System in Salmonella enterica Serovar Typhimurium Virulence

Susana Campoy,1 Mónica Jara,1 Núria Busquets,1 Ana M. Pérez de Rozas,2 Ignacio Badiola,2* and Jordi Barbé1,2*

Department of Genetics and Microbiology, Universitat Autònoma de Barcelona,1 Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona Institut de Recerca i Tecnologia Agroalimentària (UAB-IRTA), Bellaterra 08193, Barcelona, Spain2

Received 24 January 2002/ Returned for modification 2 April 2002/ Accepted 25 April 2002

The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

* Corresponding author. Mailing address: Centre de Recerca en Sanitat Animal, Universitat Autònoma de Barcelona Institut de Recerca i Tecnologia Agroalimentària, Bellaterra 08193, Barcelona, Spain. Phone: 34-93-223-4623. Fax: 34-93-223-4106. E-mail: ignacio.badiola{at}irta.es.

* Corresponding author. Mailing address: Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain. Phone: 34-93-581 1837. Fax: 34-93-581-2387. E-mail: jordi.barbe{at}uab.es.

Editor: A. D. O'Brien

Infection and Immunity, August 2002, p. 4721-4725, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4721-4725.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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