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Infection and Immunity, August 2002, p. 4743-4746, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4743-4746.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Interleukin-8 Secretion from Mycobacterium tuberculosis-Infected Monocytes Is Regulated by Protein Tyrosine Kinases but Not by ERK1/2 or p38 Mitogen-Activated Protein Kinases

Clara Ameixa,{dagger} and Jon S. Friedland*

Department of Infectious Diseases, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London, United Kingdom

Received 23 January 2002/ Returned for modification 13 March 2002/ Accepted 13 May 2002

Mycobacterium tuberculosis upregulates NF-{kappa}B binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes. Inhibition of tyrosine protein kinases but not of ERK1/2 or p38 mitogen-activated protein kinases downregulates tuberculosis-induced IL-8 secretion. The inhibitor genistein decreased NF-{kappa}B nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.

* Corresponding author. Mailing address: Dept. of Infectious Diseases, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Rd., London W12 ONN, United Kingdom. Fax: 44 20 8383 3394. E-mail: j.friedland{at}ic.ac.uk.

Editor: R. N. Moore

{dagger} Present address: The Wolfson Institute for Biomedical Research, London WC1E 6AU, England.

Infection and Immunity, August 2002, p. 4743-4746, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4743-4746.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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