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Infection and Immunity, August 2002, p. 4750-4753, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4750-4753.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Mice That Are Congenic for the char2 Locus Are Susceptible to Malaria

Rachel A. Burt,,{dagger} Vikki M. Marshall, Jamie Wagglen, Fleur R. Rodda, Danielle Senyschen, Tracey M. Baldwin, Lynn A. Buckingham, and Simon J. Foote*

The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia

Received 28 January 2002/ Returned for modification 3 April 2002/ Accepted 14 May 2002

A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.

* Corresponding author. Mailing address: The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia. Phone: 61 3 9345 2555. Fax: 61 3 9347 0852. E-mail: foote{at}wehi.edu.au.

Editor: R. N. Moore

{dagger} Present address: Rockefeller University, New York, NY 10021.

Infection and Immunity, August 2002, p. 4750-4753, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4750-4753.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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