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Infection and Immunity, September 2002, p. 4897-4901, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.4897-4901.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Protection from Group B Streptococcal Infection in Neonatal Mice by Maternal Immunization with Recombinant Sip Protein

Denis Martin,* Stéphane Rioux, Edith Gagnon, Martine Boyer, Josée Hamel, Nathalie Charland, and Bernard R. Brodeur

Unité de Recherche en Vaccinologie, Centre Hospitalier Universitaire de Québec et Université Laval, Ste-Foy, Canada G1V 4G2

Received 28 February 2002/ Returned for modification 8 April 2002/ Accepted 29 May 2002

The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.

* Corresponding author. Mailing address: Unité de Recherche en Vaccinologie, Centre Hospitalier Universitaire de Québec, Pavillon CHUL, Édifice T-367, 2705 Boul. Laurier, Ste-Foy, Québec, Canada G1V 4G2. Phone:(418) 656-4141-6206. Fax: (418) 654-2280. E-mail: Denis.Martin{at}crchul.ulaval.ca.

Editor: E. I. Tuomanen

Infection and Immunity, September 2002, p. 4897-4901, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.4897-4901.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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