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Infection and Immunity, September 2002, p. 5256-5258, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5256-5258.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Contribution of Candida albicans ALS1 to the Pathogenesis of Experimental Oropharyngeal Candidiasis

Yasuki Kamai,1* Mikie Kubota,1 Yoko Kamai,2 Tsunemichi Hosokawa,2 Takashi Fukuoka,1 and Scott G. Filler3

Biological Research Laboratories,1 Laboratory Animal Science and Toxicology Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan,2 Harbor-UCLA Research and Education Institute, Torrance, California 905023

Received 2 January 2002/ Returned for modification 17 February 2002/ Accepted 8 May 2002

We investigated the contribution of Candida albicans ALS1, which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection.

* Corresponding author. Mailing address: Biological Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan. Phone: 81-3-3492-3131. Fax: 81-3-5436-8565. E-mail: ykamai{at}shina.sankyo.co.jp.

Editor: T. R. Kozel

Infection and Immunity, September 2002, p. 5256-5258, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5256-5258.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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