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Infection and Immunity, September 2002, p. 5259-5264, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5259-5264.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Lipopolysaccharide Desensitization of Macrophages Provides Protection against Yersinia enterocolitica-Induced Apoptosis

Klaus Ruckdeschel* and Kathleen Richter

Max von Pettenkofer Institute for Hygiene and Medical Microbiology, 80336 Munich, Germany

Received 6 February 2002/ Returned for modification 18 April 2002/ Accepted 28 May 2002

Pathogenic Yersinia spp. uncouple an array of signal transduction pathways in macrophages to disrupt their response to infection. This compels the macrophage to undergo apoptosis. Our study shows that macrophages that had acquired tolerance to Yersinia infection by preexposure to lipopolysaccharide were considerably protected against Y. enterocolitica-induced apoptosis. The desensitization of macrophages by lipopolysaccharide, which is thought to be a self-protective, adaptive response to sustained bacterial stimulation, may represent an immune mechanism that aids in overcoming Yersinia-mediated apoptosis and infection.

* Corresponding author. Mailing address: Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Pettenkoferstrasse 9a, 80336 Munich, Germany. Phone: (49) 89-5160 5314. Fax: (49) 89-5160 5223. E-mail: ruckdeschel{at}m3401.mpk.med.uni-muenchen.de.

Editor: B. B. Finlay

Infection and Immunity, September 2002, p. 5259-5264, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5259-5264.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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