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Infection and Immunity, September 2002, p. 5269-5273, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5269-5273.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Mixed Periodontal Th1-Th2 Cytokine Profile in Actinobacillus actinomycetemcomitans-Specific Osteoprotegerin Ligand (or RANK-L)- Mediated Alveolar Bone Destruction In Vivo

Yen-Tung A. Teng*

Division of Periodontics and Department of Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1,1 Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6A 4G5, Canada2

Received 12 April 2002/ Returned for modification 7 May 2002/ Accepted 30 May 2002

The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.

* Mailing address: Division of Periodontics and Department of Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1. Phone: (519) 661-2111, ext. 86112. Fax: (519) 850-2316. E-mail: yateng{at}uwo.ca.

Editor: T. R. Kozel

Infection and Immunity, September 2002, p. 5269-5273, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5269-5273.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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