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Infection and Immunity, September 2002, p. 5274-5278, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5274-5278.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

ß-1,2-Mannosylation of Candida albicans Mannoproteins and Glycolipids Differs with Growth Temperature and Serotype

P. A. Trinel,1 T. Jouault,1 J. E. Cutler,2 and D. Poulain1*

Laboratoire de Mycologie Fondamentale et Appliquée, INSERM EPI 9915, Faculté de Médecine, Pôle Recherche, 59045 Lille Cedex, France,1 Research Institute for Children, Children's Hospital, New Orleans, Louisiana 701182

Received 2 January 2002/ Returned for modification 19 February 2002/ Accepted 29 May 2002

Increasing the growth temperature from 28 to 37°C reduced the expression of ß-1,2-oligomannoside epitopes on mannoproteins of Candida albicans serotypes A and B. In contrast, ß-1,2-mannosylation of phospholipomannan (PLM) remained constant despite a slight decrease in the relative molecular weight (Mr) of this compound. At all growth temperatures investigated, serotype A PLM displayed an Mr and an antigenicity different from those of serotype B PLM when they were tested with a panel of monoclonal antibodies.

* Corresponding author. Mailing address: Laboratoire de Mycologie Fondamentale et Appliquée, INSERM EPI 9915, Faculté de Médecine, Pôle Recherche, 59045 Lille cedex, France. Phone: 33-3 20 62 34 20. Fax: 33-3 20 62 34 16. E-mail: dan_poulain{at}compuserve.com.

Editor: T. R. Kozel

Infection and Immunity, September 2002, p. 5274-5278, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5274-5278.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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