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Infection and Immunity, September 2002, p. 5283-5286, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5283-5286.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Dirofilaria immitis Polyprotein Up-Regulates Nitric Oxide Production

Hiroyuki Tezuka, Shinjiro Imai, Setsuko Tsukidate, and Koichiro Fujita*

Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan

Received 25 February 2002/ Returned for modification 15 April 2002/ Accepted 11 June 2002

We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40-/-, mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.

* Corresponding author. Mailing address: Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Phone: 81-3-5803-5193. Fax: 81-3-5684-2849. E-mail: fuji.vip{at}tmd.ac.jp.

Editor: J. M. Mansfield

Infection and Immunity, September 2002, p. 5283-5286, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5283-5286.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tezuka, H., Imai, S., Hidano, S., Tsukidate, S., Fujita, K. (2003). Various Types of Dirofilaria immitis Polyproteins Selectively Induce a Th2-Type Immune Response. Infect. Immun. 71: 3802-3811 [Abstract] [Full Text]  


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