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Infection and Immunity, September 2002, p. 5299-5303, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5299-5303.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Campylobacter jejuni from Patients with Guillain-Barré Syndrome Preferentially Expresses a GD1a-Like Epitope

Irving Nachamkin,1* Jirong Liu,1 Ming Li,1 Huong Ung,1 Anthony P. Moran,2 Martina M. Prendergast,2 and Kazim Sheikh3

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283,1 Department of Microbiology, National University of Ireland, Galway, Ireland,2 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 212873

Received 12 March 2002/ Returned for modification 14 May 2002/ Accepted 14 June 2002

GM1- and GD1a-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD1a-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD1a-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.

* Corresponding author. Mailing address: Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, 4th Floor, Gates Building, 3400 Spruce St., Philadelphia, PA 19104-4283. Phone: (215) 662-6651. Fax: (215) 662-6655. E-mail: nachamki{at}mail.med.upenn.edu.

Editor: J. D. Clements

Infection and Immunity, September 2002, p. 5299-5303, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5299-5303.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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