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Infection and Immunity, September 2002, p. 5307-5311, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5307-5311.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Borrelia burgdorferi erp (ospE-Related) Gene Sequences Remain Stable during Mammalian Infection

Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298

Received 4 April 2002/ Returned for modification 21 May 2002/ Accepted 3 June 2002

A number of studies have indicated that Borrelia burgdorferi erp genes need not vary during vertebrate infection. However, it was recently reported that a B. burgdorferi bacterium reisolated from an infected mouse evidenced mutation and recombination events in several erp genes. Reexamination of that reisolate indicates that the previously reported changes were no doubt artifacts of the PCR processes originally used to clone those DNAs. Thus, no evidence has been found of erp gene variation during mammalian infection.

Editor: D. L. Burns

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