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Infection and Immunity, September 2002, p. 5312-5315, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5312-5315.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Salmonella enterica Serovar Typhimurium Periplasmic Superoxide Dismutases SodCI and SodCII Are Required for Protection against the Phagocyte Oxidative Burst

Laura M. Sly,1 Donald G. Guiney,2 and Neil E. Reiner1,3*

Department of Medicine (Division of Infectious Diseases), Faculty of Medicine,1 Department of Microbiology and Immunology, Faculty of Science, University of British Columbia, Vancouver, British Columbia, Canada,3 Department of Medicine, University of California at San Diego School of Medicine, La Jolla, California2

Received 8 April 2002/ Returned for modification 7 May 2002/ Accepted 3 June 2002

Vitamin D3 (1,25-dihydroxycholecalciferol) induced the phagocyte oxidative burst and intracellular killing of Salmonella enterica serovar Typhimurium in a phosphatidylinositol 3-kinase-dependent manner. The antimicrobial effect was more pronounced for Salmonella SodCI and SodCII mutants, confirming the role of the phagocyte oxidase in the vitamin D3 effect. The results for an in vitro system with human THP-1 cells correlate with in vivo virulence data for mice and show that both the SodCI and SodCII enzymes are required to protect against the oxidative burst.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of British Columbia, Rm. 452D, 2733 Heather St., Vancouver, British Columbia, Canada V5Z 3J5. Phone: (604) 875-4011. Fax: (604) 875-4013. E-mail: ethan{at}interchange.ubc.ca.

Editor: D. L. Burns

Infection and Immunity, September 2002, p. 5312-5315, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5312-5315.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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