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Infection and Immunity, September 2002, p. 5316-5318, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5316-5318.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Shiga Toxin 2 Induces Macrophage-Granulocyte Colonies from Human Bone Marrow and Cord Blood Stem Cells

Shin Chiyoda,1 Tae Takeda,2 and Yosuke Aoki3*

Nagasaki Red Cross Blood Center, Nagasaki,1 Department of Infectious Diseases Research, National Children's Medical Research Center,2 Department of Food and Health Sciences, Faculty of Human Life Sciences, Jissen Women's University, Tokyo, Japan3

Received 23 April 2002/ Returned for modification 17 May 2002/ Accepted 27 May 2002

Addition of Shiga toxin 2 to human bone marrow or cord blood cell culture induced macrophage-granulocyte colonies. Although Shiga toxin 2 alone induced colonies mainly composed of macrophages, it induced colonies mainly consisting of granulocytes when combined with physiological doses of interleukin-1ß, granulocyte colony-stimulating factor, or stem cell factor with interleukin-3.

* Corresponding author. Mailing address: Faculty of Human Life Sciences, Jissen Women's University, Osakaue 4-1-1, Hino-city, Tokyo, Japan 191-8510. Phone: 81-42-585-8892. Fax: 81-42-585-8892. E-mail: yaoki{at}univ.jissen.ac.jp.

Editor: J. T. Barbieri

Infection and Immunity, September 2002, p. 5316-5318, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5316-5318.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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