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Neutrophil-Mediated Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice

S. A. Fulton,^* S. M. Reba, T. D. Martin,^, and W. H. Boom

Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-4984

Received 3 December 2001/ Returned for modification 12 February 2002/ Accepted 22 May 2002

Although neutrophils have been identified as sources of inflammatory cytokines and chemokines, little is known about their immunologic function during mycobacterial infection in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and recruitment of neutrophils was associated with respective increases and decreases in M. bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.

Editor: S. H. E. Kaufmann

Present address: National Cancer Institute, Frederick, MD 21702.

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