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Infection and Immunity, September 2002, p. 5328-5331, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5328-5331.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies

Roseangela I. Nwuba,1 Olugbemiro Sodeinde,2 Chiaka I. Anumudu,1 Yusuf O. Omosun,1 Alexander B. Odaibo,1 Anthony A. Holder,3* and Mark Nwagwu1

Cellular Parasitology Programme, Department of Zoology,1 Department of Paediatrics, University College Hospital, University of Ibadan, Ibadan, Nigeria,2 Division of Parasitology, National Institute for Medical Research, London NW7 1AA, United Kingdom3

Received 21 December 2001/ Returned for modification 12 March 2002/ Accepted 29 May 2002

Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.

* Corresponding author. Mailing address: Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom. Phone: (44) 208-959-3666, ext. 2175. Fax: (44) 208-913-8593. E-mail: aholder{at}nimr.mrc.ac.uk.

Editor: J. M. Mansfield

Infection and Immunity, September 2002, p. 5328-5331, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5328-5331.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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