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Infection and Immunity, September 2002, p. 5332-5334, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5332-5334.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chlamydia pneumoniae and Hyperlipidemia Are Co-Risk Factors for Atherosclerosis: Infection Prior to Induction of Hyperlipidemia Does Not Accelerate Development of Atherosclerotic Lesions in C57BL/6J Mice

Erwin Blessing,1 Lee Ann Campbell,1 Michael E. Rosenfeld,1,2 and Cho-chou Kuo1*

Department of Pathobiology,1 Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, Seattle, Washington 981952

Received 30 March 2002/ Returned for modification 25 April 2002/ Accepted 6 May 2002

Chlamydia pneumoniae has been shown to accelerate atherosclerotic lesion development in hyperlipidemic animals. This study showed that C. pneumoniae did not accelerate lesion development in mice if a high-fat/high-cholesterol diet was started after infection, indicating that C. pneumoniae is a co-risk factor with hyperlipidemia for cardiovascular disease.

* Corresponding author. Mailing address: Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195. Phone: (206) 543-8689. Fax: (206) 543-3873. E-mail: cckuo{at}u.washington.edu.

Editor: D. L. Burns

Infection and Immunity, September 2002, p. 5332-5334, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5332-5334.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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