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Infection and Immunity, September 2002, p. 5335-5337, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5335-5337.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Yersinia High-Pathogenicity Island Contributes to Virulence in Escherichia coli Causing Extraintestinal Infections

Sören Schubert,1* Bertrand Picard,2 Stéphanie Gouriou,2 Jürgen Heesemann,1 and Erick Denamur3

Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany,1 Laboratoire de Bactériologie-Virologie, 29285 Brest Cedex,2 INSERM U 458, Hôpital Robert Debré, 75395 Paris Cedex 19, France3

Received 27 February 2002/ Returned for modification 24 April 2002/ Accepted 11 June 2002

The Yersinia high-pathogenicity island (HPI) encodes an iron uptake system mediated by the siderophore yersiniabactin (Ybt) and confers the virulence of highly pathogenic Yersinia species. This HPI is also widely distributed in human pathogenic members of the family of Enterobacteriaceae, above all in extraintestinal pathogenic Escherichia coli (ExPEC). In the present study we demonstrate a highly significant correlation of a functional HPI and extraintestinal virulence in E. coli. Moreover, using a mouse infection model, we show for the first time that the HPI contributes to the virulence of ExPEC.

* Corresponding author. Mailing address: Max von Pettenkofer-Institut, Pettenkoferstr. 9a, 80336 Munich, Germany. Phone: 49 89 5160 5261. Fax: 49 89 5160 5223. E-mail: schubert{at}pk-i.med.uni-muenchen.de.

Editor: V. J. DiRita

Infection and Immunity, September 2002, p. 5335-5337, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5335-5337.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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