This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schubert, S. Articles by Denamur, E. Search for Related Content PubMed PubMed Citation Articles by Schubert, S. Articles by Denamur, E.

 Previous Article  |  Next Article 

Infection and Immunity, September 2002, p. 5335-5337, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5335-5337.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Yersinia High-Pathogenicity Island Contributes to Virulence in Escherichia coli Causing Extraintestinal Infections

Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany,¹ Laboratoire de Bactériologie-Virologie, 29285 Brest Cedex,² INSERM U 458, Hôpital Robert Debré, 75395 Paris Cedex 19, France³

Received 27 February 2002/ Returned for modification 24 April 2002/ Accepted 11 June 2002

The Yersinia high-pathogenicity island (HPI) encodes an iron uptake system mediated by the siderophore yersiniabactin (Ybt) and confers the virulence of highly pathogenic Yersinia species. This HPI is also widely distributed in human pathogenic members of the family of Enterobacteriaceae, above all in extraintestinal pathogenic Escherichia coli (ExPEC). In the present study we demonstrate a highly significant correlation of a functional HPI and extraintestinal virulence in E. coli. Moreover, using a mouse infection model, we show for the first time that the HPI contributes to the virulence of ExPEC.

Editor: V. J. DiRita

This article has been cited by other articles:

• Caza, M., Lepine, F., Milot, S., Dozois, C. M. (2008). Specific Roles of the iroBCDEN Genes in Virulence of an Avian Pathogenic Escherichia coli O78 Strain and in Production of Salmochelins. Infect. Immun. 76: 3539-3549 [Abstract] [Full Text]  
• Hancock, V., Ferrieres, L., Klemm, P. (2008). The ferric yersiniabactin uptake receptor FyuA is required for efficient biofilm formation by urinary tract infectious Escherichia coli in human urine. Microbiology 154: 167-175 [Abstract] [Full Text]  
• Feldmann, F., Sorsa, L. J., Hildinger, K., Schubert, S. (2007). The Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro. Infect. Immun. 75: 3183-3187 [Abstract] [Full Text]  
• Durant, L., Metais, A., Soulama-Mouze, C., Genevard, J.-M., Nassif, X., Escaich, S. (2007). Identification of Candidates for a Subunit Vaccine against Extraintestinal Pathogenic Escherichia coli. Infect. Immun. 75: 1916-1925 [Abstract] [Full Text]  
• Osorio, C. R., Juiz-Rio, S., Lemos, M. L. (2006). A siderophore biosynthesis gene cluster from the fish pathogen Photobacterium damselae subsp. piscicida is structurally and functionally related to the Yersinia high-pathogenicity island.. Microbiology 152: 3327-3341 [Abstract] [Full Text]  
• Bultreys, A., Gheysen, I., de Hoffmann, E. (2006). Yersiniabactin Production by Pseudomonas syringae and Escherichia coli, and Description of a Second Yersiniabactin Locus Evolutionary Group.. Appl. Environ. Microbiol. 72: 3814-3825 [Abstract] [Full Text]  
• Sonntag, A.-K., Bielaszewska, M., Mellmann, A., Dierksen, N., Schierack, P., Wieler, L. H., Schmidt, M. A., Karch, H. (2005). Shiga Toxin 2e-Producing Escherichia coli Isolates from Humans and Pigs Differ in Their Virulence Profiles and Interactions with Intestinal Epithelial Cells. Appl. Environ. Microbiol. 71: 8855-8863 [Abstract] [Full Text]  
• Rodriguez-Siek, K. E., Giddings, C. W., Doetkott, C., Johnson, T. J., Fakhr, M. K., Nolan, L. K. (2005). Comparison of Escherichia coli isolates implicated in human urinary tract infection and avian colibacillosis. Microbiology 151: 2097-2110 [Abstract] [Full Text]  
• Lesic, B., Carniel, E. (2005). Horizontal Transfer of the High-Pathogenicity Island of Yersinia pseudotuberculosis. J. Bacteriol. 187: 3352-3358 [Abstract] [Full Text]  
• Negre, V. L., Bonacorsi, S., Schubert, S., Bidet, P., Nassif, X., Bingen, E. (2004). The Siderophore Receptor IroN, but Not the High-Pathogenicity Island or the Hemin Receptor ChuA, Contributes to the Bacteremic Step of Escherichia coli Neonatal Meningitis. Infect. Immun. 72: 1216-1220 [Abstract] [Full Text]  
• Schmidt, H., Hensel, M. (2004). Pathogenicity Islands in Bacterial Pathogenesis. Clin. Microbiol. Rev. 17: 14-56 [Abstract] [Full Text]  
• Okeke, I. N., Scaletsky, I. C. A., Soars, E. H., Macfarlane, L. R., Torres, A. G. (2004). Molecular Epidemiology of the Iron Utilization Genes of Enteroaggregative Escherichia coli. J. Clin. Microbiol. 42: 36-44 [Abstract] [Full Text]  
• Koczura, R., Kaznowski, A. (2003). The Yersinia high-pathogenicity island and iron-uptake systems in clinical isolates of Escherichia coli. J Med Microbiol 52: 637-642 [Abstract] [Full Text]  
• Redford, P., Roesch, P. L., Welch, R. A. (2003). degS Is Necessary for Virulence and Is among Extraintestinal Escherichia coli Genes Induced in Murine Peritonitis. Infect. Immun. 71: 3088-3096 [Abstract] [Full Text]  
• Sorsa, L. J., Dufke, S., Heesemann, J., Schubert, S. (2003). Characterization of an iroBCDEN Gene Cluster on a Transmissible Plasmid of Uropathogenic Escherichia coli: Evidence for Horizontal Transfer of a Chromosomal Virulence Factor. Infect. Immun. 71: 3285-3293 [Abstract] [Full Text]