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Infection and Immunity, January 2003, p. 524-526, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.524-526.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Production of Macrophage Inflammatory Protein 3{alpha} (MIP-3{alpha}) (CCL20) and MIP-3ß (CCL19) by Human Peripheral Blood Neutrophils in Response to Microbial Pathogens

Tohru Akahoshi,1* Takeshi Sasahara,2 Rie Namai,3 Toshimichi Matsui,3 Hiroyuki Watabe,3 Hidero Kitasato,2 Matsuhisa Inoue,2 and Hirobumi Kondo3

Departments of Laboratory Medicine,1 Microbiology,2 Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan3

Received 11 July 2002/ Returned for modification 26 August 2002/ Accepted 4 October 2002

Effects of bacterial pathogens on the production of macrophage inflammatory protein 3{alpha} (MIP-3{alpha}) and MIP-3ß from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. Phone: 81-42-778-9119. Fax: 81-42-778-8441. E-mail: akahoshi{at}med.kitasato-u.ac.jp.

Editor: W. A. Petri, Jr.

Infection and Immunity, January 2003, p. 524-526, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.524-526.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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