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Infection and Immunity, January 2003, p. 527-532, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.527-532.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Expression of Proinflammatory Cytokines and Receptors by Human Fallopian Tubes in Organ Culture following Challenge with Neisseria gonorrhoeae

Kevin Maisey,1* Gino Nardocci,1 Monica Imarai,1 Hugo Cardenas,1 Miguel Rios,1 Horacio B. Croxatto,2 John E. Heckels,3 Myron Christodoulides,3 and Luis A. Velasquez1

Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH),1 Instituto Chileno de Medicina Reproductiva, Santiago, Chile,2 Molecular Microbiology and Infection, Division of Infection, Inflammation and Repair, University of Southampton Medical School, Southampton, England3

Received 12 July 2002/ Returned for modification 15 September 2002/ Accepted 10 October 2002

Infection of the Fallopian tubes (FT) by Neisseria gonorrhoeae can lead to acute salpingitis, an inflammatory condition, which is a major cause of infertility. Challenge of explants of human FT with gonococci induced mRNA expression and protein secretion for the proinflammatory cytokines interleukin (IL)-1{alpha}, IL-1ß, and tumor necrosis factor alpha (TNF-{alpha}) but not for granulocyte-macrophage colony-stimulating factor. In contrast, FT expression of IL-6 and of the cytokine receptors IL-6R, TNF receptor I (TNF-RI), and TNF-RII was constitutive and was not increased by gonococcal challenge. These studies suggest that several proinflammatory cytokines are likely to contribute to the cell and tissue damage observed in gonococcal salpingitis.

* Corresponding author. Mailing address: Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, Chile. Phone: (562) 6818511. Fax: (562) 6812108. E-mail: krmaisey{at}mi-mail.cl.

Editor: W. A. Petri, Jr.

Infection and Immunity, January 2003, p. 527-532, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.527-532.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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