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Infection and Immunity, January 2003, p. 533-535, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.533-535.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vibrio vulnificus Induces Macrophage Apoptosis In Vitro and In Vivo

Takashige Kashimoto,1* Shunji Ueno,1 Miyuki Hanajima,1 Hisae Hayashi,1 Yukihiro Akeda,2 Shinichi Miyoshi,3 Toshiharu Hongo,4 Takeshi Honda,2 and Nobuyuki Susa1

Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, Towada Aomori 034-8628,1 Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871,2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-Naka, Okayama 700-8530,3 Department of Laboratory Medicine, Kurashiki Central Hospital, Kurashiki, Okayama 710-8602, Japan4

Received 30 July 2002/ Returned for modification 10 September 2002/ Accepted 27 September 2002

In this study, we compared the apoptotic activities of clinical and environmental isolates of Vibrio vulnificus toward macrophages in vitro and in vivo. The clinical isolates induced apoptosis in macrophage-like cells in vitro and in macrophages in vivo. This suggests that macrophage apoptosis may be important for the clinical virulence of V. vulnificus.

* Corresponding author. Mailing address: Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, Towada-shi, Aomori-ken 034-8628, Japan. Phone: 81-176-23-4371, ext. 443. Fax: 81-176-23-8703. E-mail: kashimot{at}vmas.kitasato-u.ac.jp.

Editor: J. T. Barbieri

Infection and Immunity, January 2003, p. 533-535, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.533-535.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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