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Infection and Immunity, January 2003, p. 562-566, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.562-566.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Feasibility of an HA2 Domain-Based Periodontitis Vaccine

A. A. DeCarlo,1 Y. Huang,2 C. A. Collyer,3 D. B. Langley,3 and J. Katz2*

Vaccine Research Division, Agenta Biotechnologies, Birmingham, Alabama 35253,1 Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294,2 Department of Biochemistry, University of Sydney, New South Wales 2006, Australia3

Received 2 July 2002/ Returned for modification 5 September 2002/ Accepted 7 October 2002

In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.

* Corresponding author. Present address: College of Dental Medicine, Nova Southeastern University, Rm. 7382, Dental, 3200 South University Dr., Ft. Lauderdale, FL 33328. Phone: (954) 262-1692. Fax: (954) 262-1692. E-mail: adecarlo{at}nova.edu.

Editor: J. D. Clements

Infection and Immunity, January 2003, p. 562-566, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.562-566.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Teng, Y.-T.A. (2006). Protective and Destructive Immunity in the Periodontium: Part 1--Innate and Humoral Immunity and the Periodontium. JDR 85: 198-208 [Abstract] [Full Text]  
  • Teng, Y.-T.A. (2006). Protective and Destructive Immunity in the Periodontium: Part 2--T-cell-mediated Immunity in the Periodontium. JDR 85: 209-219 [Abstract] [Full Text]  
  • Nguyen, K.-A., DeCarlo, A. A., Paramaesvaran, M., Collyer, C. A., Langley, D. B., Hunter, N. (2004). Humoral Responses to Porphyromonas gingivalis Gingipain Adhesin Domains in Subjects with Chronic Periodontitis. Infect. Immun. 72: 1374-1382 [Abstract] [Full Text]  
  • Kuramitsu, H. K. (2003). MOLECULAR GENETIC ANALYSIS OF THE VIRULENCE OF ORAL BACTERIAL PATHOGENS: AN HISTORICAL PERSPECTIVE. CROBM 14: 331-344 [Abstract] [Full Text]  


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