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Infection and Immunity, January 2003, p. 567-570, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.567-570.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Induction of Emetic Response to Staphylococcal Enterotoxins in the House Musk Shrew (Suncus murinus)

Dong-Liang Hu,1,2 Katsuhiko Omoe,1* Yu Shimoda,1 Akio Nakane,2 and Kunihiro Shinagawa1

Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550,a Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan,b

Received 15 July 2002/ Returned for modification 27 August 2002/ Accepted 18 September 2002

The emetic responses induced by staphylococcal enterotoxin A (SEA), SEB, SEC2, SED, SEE, SEG, SEH, and SEI in the house musk shrew (Suncus murinus) were investigated. SEA, SEE, and SEI showed higher emetic activity in the house musk shrew than the other SEs. SEB, SEC2, SED, SEG, and SEH also induced emetic responses in this animal model but relatively high doses were required. The house musk shrew appears to be a valuable model for studying the mechanisms of emetic reactions caused by SEs.

* Corresponding author. Mailing address: Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550, Japan. Phone: 81 (19) 621-6221. Fax: 81 (19) 621-6223. E-mail: omo{at}iwate-u.ac.jp.

Editor: J. T. Barbieri

Infection and Immunity, January 2003, p. 567-570, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.567-570.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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