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Infection and Immunity, January 2003, p. 571-574, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.571-574.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A Single-Copy Gene Encodes Kex1, a Serine Endoprotease of Pneumocystis jiroveci

Geetha Kutty and Joseph A. Kovacs*

Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892

Received 18 July 2002/ Returned for modification 29 August 2002/ Accepted 6 October 2002

We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.

* Corresponding author. Mailing address: Building 10, Room 7D43, MSC 1662, Bethesda, MD 20892-1662. Phone: (301) 496-9907. Fax: (301) 402-1213. E-mail: jkovacs{at}nih.gov.

Editor: T. R. Kozel

Infection and Immunity, January 2003, p. 571-574, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.571-574.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kennedy, C. C., Kottom, T. J., Limper, A. H. (2009). Characterization of a Novel ADAM Protease Expressed by Pneumocystis carinii. Infect. Immun. 77: 3328-3336 [Abstract] [Full Text]  
  • Ambrose, H. E., Keely, S. P., Aliouat, E. M., Dei-Cas, E., Wakefield, A. E., Miller, R. F., Stringer, J. R. (2004). Expression and complexity of the PRT1 multigene family of Pneumocystis carinii. Microbiology 150: 293-300 [Abstract] [Full Text]  


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