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Infection and Immunity, January 2003, p. 575-579, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.575-579.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Enhanced Immunogenicity to Mycobacterium tuberculosis by Vaccination with an Alphavirus Plasmid Replicon Expressing Antigen 85A

Joanna R. Kirman,1,{dagger} Tara Turon,1 Hua Su,2 Amy Li,3 Carl Kraus,2 John M. Polo,4 John Belisle,5 Sheldon Morris,3 and Robert A. Seder1*

Cellular Immunology Section, Vaccine Research Center,1 Laboratory of Immunogenetics,2 National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Food and Drug Administration, Bethesda, Maryland,3 Vaccines Research, Chiron Corporation, Emeryville, California,4 Microbiology Department, Colorado State University, Fort Collins, Colorado5

Received 24 July 2002/ Returned for modification 29 August 2002/ Accepted 10 September 2002

The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A. pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector.

* Corresponding author. Mailing address: Vaccine Research Center, 40 Convent Dr., Room 40/3512, NIH, Bethesda, MD 20892-3005. Phone: (301) 594-8483. Fax: (301) 480-2565. E-mail: RSEDER{at}MAIL.NIH.GOV.

Editor: T. R. Kozel

{dagger} Present address: Malaghan Institute of Medical Research, Wellington, New Zealand.

Infection and Immunity, January 2003, p. 575-579, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.575-579.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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