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Infection and Immunity, January 2003, p. 580-583, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.580-583.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Association of Helicobacter pylori Antioxidant Activities with Host Colonization Proficiency

Adriana A. Olczak, Richard W. Seyler, Jr., Jonathan W. Olson, and Robert J. Maier*

Department of Microbiology, University of Georgia, Athens, Georgia 30602

Received 1 August 2002/ Accepted 25 September 2002

To assess the importance of two separate antioxidant activities in Helicobacter pylori, we tested the abilities of strains with mutations in either tpx (encoding thiolperoxidase) or ahpC (encoding alkyl hydroperoxide reductase [AhpC]) to colonize the stomachs of mice. The tpx strain was clearly more sensitive than the parent strain to both oxygen and cumene hydroperoxide. The strain colonized only 5% of the inoculated mice. Two different classes of oxygen-sensitive ahpC mutants in the type strain (ATCC 43504) were recently described (A. A. Olczak, J. W. Olson, and R. J. Maier, J. Bacteriol. 184:3186-3193, 2002). The same two classes of mutants were recovered upon ahpC mutagenesis of the mouse-adapted strain, SS1. Neither of these mutants was able to colonize mouse stomachs, whereas 78% of the mice inoculated with the parent strain became H. pylori positive.

* Corresponding author. Mailing address: Department of Microbiology, 527 Biological Sciences Building, University of Georgia, Athens, GA 30602. Phone: (706) 542-6875. Fax: (706) 542-2675. E-mail: rmaier{at}arches.uga.edu. {dagger}Present address: Department of Microbiology, North Carolina State University, Raleigh, NC 27695.

Editor: J. T. Barbieri

Infection and Immunity, January 2003, p. 580-583, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.580-583.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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