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Infection and Immunity, January 2003, p. 584-587, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.584-587.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Biodefense-Driven Murine Model of Pneumonic Melioidosis

J. A. Jeddeloh,* D. L. Fritz, D. M. Waag, J. M. Hartings, and G. P. Andrews

Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011

Received 5 August 2002/ Returned for modification 10 September 2002/ Accepted 2 October 2002

A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.

* Corresponding author. Present address: Orion Genomics, LLC, Center for Emerging Technologies, 4041 Forest Park, St. Louis, MO 63108. Phone: (314) 615-6382. Fax: (314) 615-6975. E-mail: jjeddeloh{at}oriongenomics.com.

Editor: D. L. Burns

Infection and Immunity, January 2003, p. 584-587, Vol. 71, No. 1
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.1.584-587.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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