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Infection and Immunity, October 2003, p. 6049-6050, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6049-6050.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Type IVB Pili of Salmonella enterica Serovar Typhi Bind to the Cystic Fibrosis Transmembrane Conductance Regulator

Inez S. M. Tsui, Cecilia M. C. Yip, Jim Hackett, and Christina Morris*

Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China

Received 6 January 2003/ Returned for modification 10 April 2003/ Accepted 14 July 2003

Salmonella enterica serovar Typhi expresses type IVB pili. We show that the prePilS protein (the soluble precursor form of the structural pilin) interacts with a 15-mer peptide representing the first extracellular domain of the cystic fibrosis transmembrane conductance regulator (CFTR), a recognized human epithelial cell receptor for serovar Typhi (G. B. Pier et al., Nature 393:79-82, 1998). This indicates that after mediating bacterial self-association (C. Morris et al., Infect. Immun. 71:1141-1146, 2003), the pili then act to attach the bacterial clumps to CFTR in the membrane of gut epithelial cells. These sequential type IVB pilus-mediated events cannot be performed by (for example) S. enterica serovar Typhimurium, which may explain why only serovar Typhi causes epidemics of enteric fever in humans.

* Corresponding author. Mailing address: Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. Phone: 852 2358-7275. Fax: 852 2719-8158. E-mail: bctina{at}ust.hk.

Editor: V. J. DiRita

Infection and Immunity, October 2003, p. 6049-6050, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6049-6050.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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