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Infection and Immunity, October 2003, p. 6058-6062, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6058-6062.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice

Max-Planck-Institut für Immunbiologie, 79108 Freiburg,¹ Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Munich, Germany,² Institute of Anatomy, Faculty of Medicine,³ Department of Clinical Medicine, Immunology and Infectious Diseases, Faculty of Medicine, University of Bari, Policlinico, 70124 Bari, Italy⁴

Received 6 March 2003/ Returned for modification 5 April 2003/ Accepted 14 July 2003

The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.

Editor: F. C. Fang

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