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Infection and Immunity, October 2003, p. 6075-6078, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6075-6078.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Serum Amyloid P Component Binding to Shiga Toxin 2 Requires Both A Subunit and B Pentamer

Paola Marcato, Kathleen Vander Helm, George L. Mulvey, and Glen D. Armstrong*

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

Received 3 June 2003/ Returned for modification 8 July 2003/ Accepted 24 July 2003

Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Phone: (780) 492 2303. Fax: (780) 492 7521. E-mail: glen.armstrong{at}ualberta.ca.

Editor: J. T. Barbieri

Infection and Immunity, October 2003, p. 6075-6078, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6075-6078.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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