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Infection and Immunity, October 2003, p. 6079-6082, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6079-6082.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Streptococcus pyogenes Infection in Mouse Skin Leads to a Time-Dependent Up-Regulation of Protein H Expression

Tara C. Smith,1,{dagger} Darren D. Sledjeski,1 and Michael D. P. Boyle2*

Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614-5806 ,1 Department of Biology, Juniata College, Huntingdon, Pennsylvania 166522

Received 23 December 2002/ Returned for modification 18 March 2003/ Accepted 27 June 2003

Streptococcus pyogenes protein H (sph) is an immunoglobulin-binding protein present in the Mga regulon of certain M1 serotype isolates. Although sph is present in many strains, it is frequently not expressed. In this paper we show that protein H was highly expressed after bacteria were injected into the skin of mice and were recovered from the blood, kidney, or spleen at various times postinfection. The percentage of protein H-positive colonies increased with time, reaching 100% in the spleen and kidney within 24 to 72 h postinfection. The up-regulation of sph expression was also observed in a mga mutant.

* Corresponding author. Mailing address: Department of Biology, Juniata College, 1700 Moore St., Huntingdon, PA 16652. Phone: (814) 641-3553. Fax: (814) 641-3685. E-mail: boyle{at}juniata.edu.

Editor: J. N. Weiser

{dagger} Present address: Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109-2029.

Infection and Immunity, October 2003, p. 6079-6082, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6079-6082.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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