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Infection and Immunity, November 2003, p. 6292-6297, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6292-6297.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

New Rat Model of Pneumocystis Pneumonia Induced by Anti-CD4+ T-Lymphocyte Antibodies

Timothy D. Thullen,1,2,3 Alan D. Ashbaugh,2 Kieran R. Daly,2 Michael J. Linke,1,2 Paul E. Steele,3,4 and Peter D. Walzer1,2,3*

Veterans Affairs Medical Center,1 Division of Infectious Disease, Department of Internal Medicine,2 Department of Pathology, University of Cincinnati College of Medicine,3 Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 452204

Received 1 July 2003/ Returned for modification 24 July 2003/ Accepted 11 August 2003

The CD4+ T lymphocyte plays a central role in host defense against Pneumocystis pneumonia but has received only limited attention in rats. CD4+ T-cell-depleting (OX-38) and nondepleting (W3/25) monoclonal antibodies, which recognize an identical or adjacent epitope, were administered for up to 14 weeks to Lewis rats that had been exposed to Pneumocystis. While OX-38 produced a greater decrease in circulating CD4+ cells than W3/25, both antibody treatments resulted in similar effects on the health of the rats and the levels of Pneumocystis pneumonia, which were milder than those found with corticosteroids. W3/25 also did not enhance the severity of Pneumocystis pneumonia achieved with corticosteroids alone. We conclude that CD4+ cell function is more important than CD4+ cell number in host defense against Pneumocystis in the rat and that this new model permits study of opportunistic infections in the rat without the confounding effects of corticosteroids.

* Corresponding author. Mailing address: Research Service (151), Veterans Affairs Medical Center, 3200 Vine St., Cincinnati, OH 45220. Phone: (513) 475-6338. Fax: (513) 475-6415. E-mail: peter.walzer{at}med.va.gov.

Editor: T. R. Kozel

Infection and Immunity, November 2003, p. 6292-6297, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6292-6297.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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